WebJun 14, 2024 · Spindly was widely thought to be a signaling kinase but the recognition that it was a glycosyltransferase had profound implications for cellular signaling. ... It is also clear that O-GlcNAc cycling plays an essential role in polycomb repression [16, 17, ... While the role of OGT and O-GlcNAc in T cell activation has been clearly established, ... WebFeb 27, 2024 · 1. Introduction. This short article is intended to provide a brief introduction to the structures of glycosaminoglycans (GAGs) and proteoglycans (PGs) to set the articles in this special issue of Pharmaceuticals on “Proteoglycans and Glycosaminoglycans” into context.The class of glycosylated proteins known as PGs is represented in the …
(PDF) Essential role of O-GlcNAcylation in stabilization of …
WebMar 3, 2024 · eases including cancer. Despite its essential role in biology, the mechanisms by which EGFR signaling is regulated in cells are still poorly understood. Here, we … WebInhibitors of O-GlcNAcase, the enzyme removing O-GlcNAc, are useful tools for studying the role of O-GlcNAc in a range of cellular processes. We report the discovery of … homemade foldable wood chair
The human O-GlcNAcome database and meta-analysis Scientific Data
WebJun 14, 2024 · Spindly was widely thought to be a signaling kinase but the recognition that it was a glycosyltransferase had profound implications for cellular signaling. ... It is also … WebJan 1, 2014 · Experimentally decreasing OGT and/or O-GlcNAc levels results in cells that are less stress tolerant, whereas increasing the levels of OGT and/or O-GlcNAc results in cells that are more viable after severe stress. ... Cell signaling, the essential role of O-GlcNAc! Biochim Biophys Acta, 1761 (2006), pp. 599-617. View PDF View article View in ... WebMay 22, 2014 · Multiple cancers contain elevated levels of O-GlcNAc transferase (OGT). Ferrer et al. show that OGT and O-GlcNAcylation play a critical role in cancer-driven glycolysis and stress survival signaling by regulating the degradation of the hypoxia-inducible factor 1 (HIF-1α). homemade folding bed camper