Cisplatin oxaliplatin

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August undefined, 2024

WebJul 7, 2014 · Cisplatin (cis-[PtCl2(NH3)2]), carboplatin ([Pt(O,O'-cdbca)(NH3)2], cbdca = cyclobutane-1,1-dicarboxylate) and oxaliplatin ([Pt(R,R-cyclohexane-1,2-diamine)(O,O′-ethanedioato)]) are used in combination with other agents to treat a range of malignancies including testicular, ovarian, head and neck, bladder, esophageal, and small cell lung … WebResults: Cisplatin-induced neuropathy was more similar to neuropathy in patients receiving oxaliplatin than in those receiving paclitaxel. The cisplatin and oxaliplatin groups exhibited the coasting phenomenon and more prominent upper extremity symptoms than lower extremity symptoms during chemotherapy administration weeks.

Platinum-Based Chemotherapy: Uses, Effectiveness, Side …

WebMay 20, 2010 · Oxaliplatin [ [ (1 R ,2 R )-cyclohexane-1,2-diamine] (ethanedioate- O, 𝑂 )platinum (II)] is a third-generation platinum compound widely used for the treatment of metastatic colorectal cancer and a variety of other malignancies, such as breast cancer, melanoma, non-Hodgkin lymphoma, and head and neck cancer [ 23 – 25 ]. WebAs compared with cisplatin, oxaliplatin was associated with significantly less grade 3 or 4 neutropenia and alopecia but significantly more grade 3 or 4 diarrhea and peripheral neuropathy. Grade... flying fish studio

Cisplatin in cancer therapy: molecular mechanisms of action

WebHowever, the RUNX1 (rs2014300) genotypes were not significantly associated with the OS of patients who received chemotherapy based on cisplatin or oxaliplatin in the dominant models. Therefore, these results demonstrated that 2R/3R and 2R/2R were hazards for patients’ prognosis involving adjuvant chemotherapy based on cisplatin (CDDP). WebMar 3, 2024 · Oxaliplatin before autologous transplantation in combination with high-dose cytarabine and rituximab provides longer disease control than cisplatin or carboplatin in patients with mantle-cell ... WebAug 5, 2015 · Abstract. Oxaliplatin was the first platinum drug with proven activity against colorectal tumors, becoming a standard in the management of this malignancy. It is also considered for the treatment of pancreatic and gastric cancers. However, a major reason for treatment failure still is the existence of tumor intrinsic or acquired resistance. … green line down iphone

A subset of platinum-containing chemotherapeutic agents kills

Cisplatin and oxaliplatin induce similar immunogenic changes …

WebJul 14, 2014 · The platinum drugs cisplatin, carboplatin, and oxaliplatin are highly utilized in the clinic and as a consequence are extensively studied in the laboratory setting. In this study, we examined the literature and found a significant number of studies (11%–34%) in prominent cancer journals utilizing cisplatin dissolved in DMSO. WebFeb 16, 2024 · Cisplatin is used together with other cancer drugs to treat bladder cancer, testicular cancer, or ovarian cancer. Cisplatin may also be used for purposes not listed in this medication guide. Warnings Cisplatin can affect your nervous system, increase your risk of bleeding or infection, or harm your kidneys. flying fish ship spelljammerWebCisplatin is known to produce significant toxicity to both the CNS and PNS, in a cumulative and dose-dependent manner. Carboplatin and oxaliplatin can produce a similar spectrum of neurological toxicities, but to a much lesser extent. The most frequent neurotoxic side-effects of cisplatin involve the PNS (see Chapter 60 ). green line down monitor

"WebOxaliplatin is used to treat colon or rectal cancer that has spread (metastasized), it is often given in combination with other anticancer drugs (fluorouracil and leucovorin). Note: If a drug has been approved for one use, physicians sometimes elect to use this same drug for other problems if they believe it might be helpful. " - Cisplatin oxaliplatin

Cisplatin oxaliplatin

Pharmaceutics Free Full-Text Pd (II) and Pt (II) Trinuclear ...

WebApr 10, 2024 · In addition, Pd-based chelates are expected to display a higher tolerability and safety profiles as compared to cisplatin, carboplatin or oxaliplatin [12,19,20], a major advantage for proceeding with preclinical and clinical evaluations. Similar to conventional Pt(II)-based drugs (e.g., cisplatin), DNA interactions are the main mode of action ...

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WebOxaliplatin, sold under the brand name Eloxatin among others, is a cancer medication (platinum-based antineoplastic class) used to treat colorectal cancer. It is given by … Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths injectable...

WebSep 9, 2014 · Cisplatin is a common and effective cancer drug. It has revolutionized the treatment of advanced germ cell tumors which were previously considered highly fatal.1 … WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be …

WebMay 22, 2024 · Gastric cancer: Oxaliplatin and cisplatin confer similar survival in elderly patients. Publish date: May 22, 2024. Clinical Edge Journal Scan: Gastric Cancer June 2024 (4 of 11) Commentary: Gastric Cancer Chemotherapy in Select Populations, June 2024; WebFeb 5, 2024 · Cisplatin and Oxaliplatin: Our Current Understanding of Their Actions. Following the serendipitous discovery of the anticancer activity of cisplatin over 50 years ago, a deep understanding of the chemical and biochemical transformations giving rise …

WebSystemic cisplatin and oxaliplatin induced similar tumor growth delay when combined with anti-PD-1 therapy. Conclusions: Treatment of HNSCC cells with platinum chemotherapy appears to induce some features of anti-tumor immunity, which may be …

WebPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of human neoplasms. Their clinical success is, however, limited due to severe side effects and intrinsic or acquired resistance to the treatment. Much effort has been put into the development of new platinum a … Platinum-based drugs: past, present and future greenline economy classWebJun 15, 2024 · We could not detect survival differences between patients treated with cisplatin versus oxaliplatin. Diarrhea more frequently impacted patients treated with oxaliplatin than patients treated with cisplatin. As hydration is not needed for oxaliplatin, it is more practical to use in daily care. green line economylass ticket priceWebOxaliplatin is a platinum complex with a (1R,2R)-1,2 diaminocyclohexane (DACH) ligand and oxalate as leaving groups. The bidentate oxalate significantly reduces reactivity of oxaliplatin and thereby limits toxic side effects, such as peripheral sensory neuropathy. green line down monitor ledWebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), … greenline earthworksWebOct 5, 2014 · Cisplatin and oxaliplatin in combination with quercetin and thymoquinone in human ovarian tumour models is the best combination to treat ovarian cancer (Nessa, Beale et al., 2011). Olaparib in combination with Cisplatin has a synergistic effect on PTEN-Deficient lung cancer Cells (Minami, Takigawa et al., 2013). flying fish sup boardsWebFeb 28, 2024 · Complex 41 was the only compound selected for the in vitro experiments, although its cytotoxicity was reduced in comparison with oxaliplatin and cisplatin in the … green line down side of iphone xWebDoes resection after neoadjuvant chemotherapy of docetaxel, oxaliplatin, and S-1 (DOS regimen) benefit for gastric cancer patients with single non-curable factor? a multicenter, prospective cohort study (Neo-REGATTA) ... (S-1 + cisplatin) had no survival advantage compared to the continuous chemotherapy group, with median OS times of 14.3 ... flying fish swim club