http://csg.sph.umich.edu/abecasis/publications/pdf/Annual.Review.Genomics.Hum.Genet.vol.10-pp.387.pdf WebFeb 2, 2024 · A 2-step imputation contains the following 2 steps: (step 1) a representative subset of >= 200 unrelated individuals are used to calibrate model parameters; and (step 2) actual genotype imputation is performed for every person using parameters inferred in step 1. Example command lines for a 2-step imputation: # step 1:
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Odyssey: a semi-automated pipeline for phasing, imputation, …
http://csg.sph.umich.edu/abecasis/publications/pdf/Annual.Review.Genomics.Hum.Genet.vol.10-pp.387.pdf Web3 main reasons for imputation Meta-analysis Fine Mapping Combining data from different chips Other less common uses sporadic missing data imputation correction of genotyping errors imputation of non-SNP variation WebSep 10, 2015 · It is an algorithm for genotypic imputation that works on phased genotypes and is designed to handle very large reference panels in a more computationally efficient … straightening the edge on a straight razor