Web15 de nov. de 2024 · In this review, we discuss the basics of spindle formation during oocyte meiotic maturation focusing on mouse and human studies. ... RanGTP and importin beta regulate meiosis I spindle assembly and function in mouse oocytes. EMBO J. 2024; 39: e101689. Google Scholar. Crossref. Web15 de jul. de 2024 · Here, porcine oocytes were selected to reveal the spatiotemporal and function of TPX2 in microtubule spindle assembly during meiotic maturation. Furthermore, these results will help to further extend an understanding of the potential etiology of porcine oocyte maturation defects. Section snippets Ethics statement
The conserved AAA ATPase PCH-2 distributes its regulation of …
WebHá 1 dia · Mammalian oocyte maturation involves two successive meiotic divisions, and these are accompanied by a series of molecular events, including germinal vesicle breakdown (GVBD), spindle assembly, extrusion of the first polar body (PB1), and finally arrest at meiotic metaphase II (MII) (Mihajlovic & FitzHarris, 2024). birch bay accounting
Ndc80 Regulates Meiotic Spindle Organization ... - Cambridge Core
Web10 de mai. de 2011 · Here, we report Ndc80 expression, localization, and possible functions in mouse oocyte meiosis. Ndc80 mRNA levels gradually increased during meiosis. Immunofluorescent staining showed that Ndc80 was restricted to the germinal vesicle and associated with spindle microtubules from the Pro-MI to MII stages. Web6 de set. de 2024 · RAN–GTP hereby facilitates local microtubule nucleation at chromosomes and assembly of a meiotic spindle. ... Furthermore, healthy mitochondrial function is essential for oocyte development 165. Web28 de mai. de 2024 · Blocking CPSF function in mouse oocytes leads to impaired meiotic spindle assembly and PB1 emission. These phenotypes resemble those observed following blockade of PAPα in the current study. These results indicate that the interaction between PAPα and CPSF has a significant role in oocyte meiotic maturation. birch bay 14 day forecast