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Ptf1a-creert2

Web036577 B6.129S6(Cg)- Ptf1a tm2(cre/ESR1)Cvw /J The Ptf1a Cre-ERTM knock-in allele was designed to both abolish pancreas specific transcription factor, 1a ( Ptf1a ) gene function and express CreERTM fusion protein from the Ptf1a promoter/enhancer elements. PTF1A effects growth and lineage specification of pancreatic multipotent progenitor cells during … WebCreERT2重组酶的活性特异表达在胰腺腺泡，有少量细胞漏表达；在小脑、垂体和胃粘膜下层有极少量细胞表达。 未检测到表达的组织包括：胸腺、心脏、肺、肝、睾丸、肾、小肠 …

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WebNov 11, 2024 · The Ptf1a(P48)-Cre mouse allele is a pancreas tissue-specific and acinar cell-specific driver model 32,34,59,60. ... Kras activation in acinar cells using the Mist1-CreERT2, ... WebHowever, to date it has remained unclear whether, as in mammals, ptf1a-expressing zebrafish pancreatic progenitors are able to contribute to multiple exocrine and endocrine lineages. To delineate the lineage potential of ptf1a-expressing cells, we generated ptf1a:creERT2 transgenic fish and performed genetic-inducible Developmental Dynamics thingaverse golden gun https://simobike.com

BPTF is required for c-MYC transcriptional activity and in vivo ...

WebNumbers of Ptf1a + Sox9 + cells decreased rapidly as organogenesis progressed. (P) Schematic, lineage potency of Ptf1a + Sox9 + Hnf1 + tip MPC during the 2° transition. Scale bars: 50 mm. from ... WebJun 17, 2024 · More specific lineage tracing analysis showed that acinar specific Ptf1a CreERT2 Kras G12D Arid1a f/f mice developed PanINs but not IPMNs after tamoxifen injection. In comparison , while oncogenic Kras G12D in adult ductal cells ( Hnf1 CreERT2 Kras G12D ) alone did not induce any sign of ductal atypia, Hnf1 CreERT2 Kras G12D … Web图 2 Tamoxifen 诱导后，Ptf1a CreERT2/+; Rosa26 tdTomato/+ 小鼠各组织中tdTomato的表达情况。. CreERT2重组酶的活性特异表达在胰腺腺泡，有少量细胞漏表达；在小脑、垂体和胃粘膜下层有极少量细胞表达。. 未检测到表达的组织包括：胸腺、心脏、肺、肝、睾丸、肾 … thingaverse lacrosse

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing …

Category:Ptf1a pancreas specific transcription factor, 1a [ (house mouse)]

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Ptf1a-creert2

PTF1A pancreas associated transcription factor 1a [ (human)]

WebDownload scientific diagram Pdx1 and Ptf1a transcription factors control early steps of pancreas specification. a Wholemount immunofluorescence for Pdx1 in an E10.5 mouse embryo revealing the ...

Ptf1a-creert2

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Webcerebellar cortex. The data in Figure S1 also demonstrate that Ptf1a+ cells in the PWM, which we show respond to Shh, contribute exclusively to GABAergic interneurons. Figure S2. Figure S2 provides important results from our Gli1 fate-mapping studies that are essential to our interpretation of the data presented in Figure 2. WebPtf1a F TCA CAT GTG TTT CTA TAA GCT GTT TG. WT = 250 bp mut = 350 bp Ptf1a R ATA CCA GCA GGT TGT TAT CTA GAG Ptf1a Null F1 GGGTCAAATCCAATATTCTC Null = ~320bp Ptf1a Null R1 AGGTTGTTATCTAGAGCCAG Isl1-Flox F1 TCT CTC ATT GGG GAA GCA AC WT=411 bp Flox=513 bp Isl1-Flox R1 TCC AGT GAA GGC CTT CC AGT Null = ~500bp Isl1 …

WebTo delineate the lineage potential of ptf1a-expressing cells, we generated ptf1a:creERT2 transgenic fish and performed genetic-inducible lineage tracing in developmental, regenerating, and ptf1a-deficient zebrafish pancreas. Results: In addition to their contribution to the acinar cell lineage, ptf1a-expressing cells give rise to both ... WebJul 7, 2015 · The protein PTF1A is crucial for establishing the differentiation state of acinar cells. In the most common form of pancreatic cancer, acinar cells are reprogrammed to …

WebEgfr f/f ;Ptf1a FlpO/+ ;FSF-Rosa26 CAG-CreERT2 mice allow conditional deletion of EGFR in pancreatic epithelial cells in a timely manner by the administration of tamoxifen (Wen et … WebPtf1a is preferably assembled into a transcription trimeric complex PTF1 with an E protein and Rbpj (or Rbpjl). In pancreatic development, Ptf1a is indispensable in controlling the …

WebPTF1A effects growth and lineage specification of pancreatic multipotent progenitor cells during development. This strain has been replaced by a C57BL/6J congenic version as …

WebThe results confirm the presence of multipotent ptf1a‐expressing progenitor cells in developing zebrafish pancreas, with reduced pTF1a dosage promoting greater contributions towards non‐acinar lineages and underscoring the central role of p TF1a in foregut tissue specification. Background: Pancreas development in zebrafish shares many features with … saints row the third romhttp://en.modelorg.com/upload/pdf/Ptf1a-CreERT2.en-us.pdf saints row the third save game locationWebPtf1a(P48)-Cre driver mouse allele32 –34,55 60. Pdx1 is not a ... CreERT2, proCPA1-CreERT2, or Ela-CreERT2 mouse alleles also shows PanIN development with focal cystic neoplasia33,61. On the thingaverse living hinge